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ABT-888 dihydrochloride (10 μM) suppresses the surviving fraction (SF) by 43% in the clonogenic H1299 cells
InChi: InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4
AT-56 inhibits the L-PGDS activity in a competitive manner against the substrate PGH2 (Km = 14 μm) with a Ki value of 75 μm
EOL-1 xenograft growth delay
BI-3663, PTK2/FAK PROTAC 632 ABT-888 dihydrochloride (10 μM) suppressesBI 3663 is a highly selective PTK2 FAK PROTAC (DC50=30 nM), with cereblon ligands to hijack E3 ligases for PTK2 degradation. BI 3663 inhibits PTK2 with an IC50 of 18 nM. BI 3663 is a PROTAC that composes of BI 4464 (HY 124625) linked to Pomalidomide (HY 10984) with a linker. Anti cancer activity. Product information CAS Number: 2341740 84 7 Molecular Weight: 917. 84 Formula: C44H42F3N7O12 Chemical Name: N [2 (2, 6 dioxopiperidin 3 yl) 1, 3 dioxo 2, 3
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